Formamide synthesis

1synthesis methods

Product Name:Formamide
CAS Number:75-12-7
Molecular formula:CH3NO
Molecular Weight:45.04

Formamide is produced commercially by two processes (Eberling 1980). In a direct synthesis, ammonia and carbon monoxide react at 100-300 atm and 80-100°C in methanolic sodium methoxide. In the second, a two-stage synthesis, carbon monoxide and methanol form methylformate in the presence of sodium methoxide. The methylformate is treated with liquid or gaseous ammonia at 2-6 atm and 80-100°C.

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Yield:-

Reaction Conditions:

in various solvent(s) at -263.16;Irradiation;Isomerization;

References:

Maier, Guenther;Endres, Joerg [European Journal of Organic Chemistry,2000,# 6,p. 1061 - 1063]

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Formamide synthesis

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