ethyl 4-chloro-2-(hydroxyimino)-3-oxobutyrate synthesis
- Product Name:ethyl 4-chloro-2-(hydroxyimino)-3-oxobutyrate
- CAS Number:50382-11-1
- Molecular formula:C6H8ClNO4
- Molecular Weight:193.585
5408-04-8
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Yield:50382-11-1 325 g
Reaction Conditions:
with sulfuryl dichloride;sulfuric acid at 5; under 1050.11 Torr; for 0.333333 h;
Steps:
1.3-3.3 (3) chlorination reaction:
prepare qualified 2-(hydroxyimino) ethyl acetoacetate ethanol solution 280g and catalyzer vitriol oil 6.0g enter from the A channel of pipeline reactor, feed rate is 12ml/min; Sulfonyl chloride 320g enters from the B channel of the pipeline reactor, the feed rate is 30ml/min; the raw materials enter the pipeline reactor through the A channel and the B channel respectively for reaction, the reaction temperature is 5, the residence time is 20min, and the pressure is 0.14Mpa. Detecting 4.0% of oxime residues is qualified, and if the oxime residues are unqualified, continue to circulate until the residues are qualified to obtain 325g of ethyl 4-chloro-2-hydroxyimino acetoacetate chloride; wherein, the pipeline reactor is a conventional pipeline reactor , the pipeline reactor is provided with A channel and B channel, and the material enters the pipeline reactor through the A channel and the B channel respectively for reaction.
References:
CN114031575,2022,A Location in patent:Paragraph 0046; 0049; 0051; 0054; 0056; 0059
638-07-3
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141-97-9
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