ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE synthesis
- Product Name:ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE
- CAS Number:5408-04-8
- Molecular formula:C6H9NO4
- Molecular Weight:159.14
141-97-9
788 suppliers
$5.00/25g
5408-04-8
66 suppliers
$32.00/500mg
Yield:5408-04-8 99%
Reaction Conditions:
Stage #1: ethyl 3-oxobutanoatewith glacial acetic acid;NaNO2 in lithium hydroxide monohydrate at 0;
Stage #2: with Sodium hydrogenocarbonate in lithium hydroxide monohydrate; pH=7 - 8;
Steps:
10.1
To a solution of compound 1 (5.20 g, 40.0 mmol) in 6 ml AcOH was added a solution of NaNC-2 (3.60 g, 52.0 mmol) in 6 ml water at 0°C. After stirred at 0°C for overnight, saturated aqueous solution of NaHCC?3 was added to adjust pH to 7-8, then brine was added, and the mixture was extracted with ethyl acetate, dried by anhydrous Na2S04, concentrated to afford compound 27 (6.35 g , 99% yield).
References:
WO2012/144661,2012,A1 Location in patent:Page/Page column 84
998-91-4
41 suppliers
$14.14/250mgs:
5408-04-8
66 suppliers
$32.00/500mg
570-08-1
113 suppliers
$30.00/5g
5408-04-8
66 suppliers
$32.00/500mg
141-97-9
788 suppliers
$5.00/25g
64-19-7
1553 suppliers
$10.00/25ML
5408-04-8
66 suppliers
$32.00/500mg
