ChemicalBook CAS DataBase List Diphenhydramine Hydrochloride

Diphenhydramine Hydrochloride synthesis

8synthesis methods

Product Name:Diphenhydramine Hydrochloride
CAS Number:147-24-0
Molecular formula:C17H22ClNO
Molecular Weight:291.82

Diphenhydramine Hydrochloride synthesis is a four-step sequence starting with a Grignard reaction.

Synthesis of Diphenhydramine Hydrochloride 6.
A) modified synthetic route to diphenhydramine hydrochloride.
B) Sequence of unit operations required for the synthesis. The dotted boxes denote the four stages of the synthesis. DMAE: dimethylaminoethanol.
Organic synthesis in a modular robotic system driven by a chemical programming language

58-73-1 Synthesis

58-73-1
278 suppliers
$10.00/1g

147-24-0
680 suppliers
$5.00/250mg

Yield:147-24-0 9.6 mmol

Reaction Conditions:

with hydrogenchloride in ethanol at 20; for 1 h;Time;

Steps:

10 Example 10

The method for preparing diphenhydramine hydrochloride adopts the preparation method of diphenhydramine according to any one of the embodiments 6-9, and after preparing diphenhydramine, the obtained diphenhydramine is dissolved in 5.0 mol ethanol solution. in. Then, dry hydrogen chloride gas was added to saturation, stirred at room temperature for 1 hour, and the solvent was evaporated under reduced pressure to obtain diphenhydramine hydrochloride.

References:

CN107673945,2018,A Location in patent:Paragraph 0028; 0029; 0030; 0031