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ChemicalBook CAS DataBase List Diethyl aminomalonate hydrochloride
13433-00-6

Diethyl aminomalonate hydrochloride synthesis

1synthesis methods
Diethyl aminomalonate hydrochloride is a pharmaceutical intermediate that can be prepared by reacting diethyl hydroxymethylnitromalonate with ammonia as an initial raw material and then forming a salt with hydrogen chloride. It has been reported to be used in the preparation of antagonists of P2Y14R and PDE1 inhibitors.
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Yield:13433-00-6 10.1 g

Reaction Conditions:

Stage #1:diethyl oximinomalonate with acetic acid;zinc in methanol at 20;
Stage #2: with hydrogenchloride in diethyl ether

References:

Chen, Fener;Ke, Miaolin;Li, Yaling;Liu, Jinxin;Liu, Minjie;Xiao, You-Cai;Zhan, Pingping [Journal of Organic Chemistry,2020,vol. 85,# 23,p. 15360 - 15367]

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