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ChemicalBook CAS DataBase List Cyclohexylhydrazine hydrochloride
24214-73-1

Cyclohexylhydrazine hydrochloride synthesis

4synthesis methods
60295-21-8 Synthesis
TERT-BUTYL 2-CYCLOHEXYLHYDRAZINECARBOXYLATE

60295-21-8
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Yield:24214-73-1 100%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;Reflux;

Steps:

161.3 Example 161: 4-chloro-N-(4-chlorophenyl)-1-cyclohexyl-3-methyl-1H-pyrazolo [3,4-b]pyridine-5-carboxamide

General procedure: To a solution of tert-butyl 2-cyclohexylhydrazine-1-carboxylate (1 .9g, 8 .87mmol) in dioxane was added HCl/dioxane (20 mL), it was then refluxed overnight. The white precipitate was filtrated to afford 1.8g (yield:>100%) of cyclohexylhydrazine hydrochloride as a white solid.

References:

WO2016/123392,2016,A2 Location in patent:Paragraph 00476

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