1,3-Cyclohexanedicarboxylic acid synthesis
- Product Name:1,3-Cyclohexanedicarboxylic acid
- CAS Number:3971-31-1
- Molecular formula:C8H12O4
- Molecular Weight:172.18
121-91-5
585 suppliers
$6.00/10g
3971-31-1
151 suppliers
$6.00/1g
Yield:3971-31-1 96.3%
Reaction Conditions:
with hydrogen;acetic acid in methanol
Steps:
1,3-cyclohexanedicarboxylic acid
1,3-cyclohexanedicarboxylic acid To a suspension of isophthalic acid (500 g, 3 mol) in methanol (2.81) was added 5% Rhodium-on-alumina catalyst (50 g) and acetic acid (150 ml). The reaction mixture was shaken under hydrogen (50 psi) at room temperature overnight. The mixture was filtered through celite. To this solution was added fresh 5% Rhodium-on-alumina catalyst (25 g), and the mixture was shaken under 50 psi of hydrogen for another 24 hours. The final reaction mixture was filtered through celite. The solution was concentrated under vacuum to give 493 g of the title compound as a white powder (96.3 % yield). m.p. 163-165° C.
References:
Bonjouklian, Rosanne;Cohen, Jeffrey Daniel;Gruber, Joseph Michael;Johnson, Douglas Webb;Jungheim, Louis Nickolaus;Kroin, Julian Stanley;Lander, Peter Ambrose;Lin, Ho-Shen;Lohman, Mark Christopher;Muehl, Brian Stephen;Norman, Bryan Hurst;Patel, Vinod Francis;Richett, Michael Enrico;Thrasher, Kenneth Jeff;Vepachedu, Sreenivasarao;White, Wesley Todd;Xie, Yongping;York, Jeremy Schulenburg;Parkhurst, Brandon Lee US2003/100576, 2003, A1
121-91-5
585 suppliers
$6.00/10g
3971-31-1
151 suppliers
$6.00/1g
13293-59-9
42 suppliers
$45.00/50mg
121-91-5
585 suppliers
$6.00/10g
3971-31-1
151 suppliers
$6.00/1g
13293-59-9
42 suppliers
$45.00/50mg
100-49-2
328 suppliers
$6.00/10g
98-89-5
382 suppliers
$13.00/25g
21651-12-7
37 suppliers
$686.79/250mg
79-10-7
698 suppliers
$20.16/100 mL
3971-31-1
151 suppliers
$6.00/1g
2305-32-0
268 suppliers
$10.00/5g