AMifaMpridine Phosphate synthesis
- Product Name:AMifaMpridine Phosphate
- CAS Number:446254-47-3
- Molecular formula:C5H10N3O4P
- Molecular Weight:207.1244
54-96-6
363 suppliers
$5.00/100mg
446254-47-3
6 suppliers
inquiry
Yield:446254-47-3 16.6 g
Reaction Conditions:
with phosphoric acid in dimethyl sulfoxide at 15 - 20;
Steps:
4; 5 Preparation of Amifampridine Phosphate (I)
Amifampridine (10 gm) was charged in to reaction flask containing DMSO (40.0 ml). cool the reaction mass to 15-20° C. ortho Phosphoric acid (17 ml) was added under stirring at 15-20° C. Charge acetone (167.0 ml) into the reaction mass at 20-25° C. and continue stirring for 10-15 minutes. Cooled the reaction mass to 0-5° C. and continue stirring for 3 to 4 hours at 0-5° C. Filtered the material and washed with Acetone (100.0 ml). Dried the material under vacuum at 40-45° C. for 6 hours to 10 hours to yield highly pure Amifampridine phosphate. Yield: 16.6 gm Chromatographic Purity (By HPLC): 99.90%
References:
US2022/127231,2022,A1 Location in patent:Paragraph 0077-0087
1681-37-4
342 suppliers
$5.00/1g
446254-47-3
6 suppliers
inquiry
504-24-5
487 suppliers
$10.00/1g
446254-47-3
6 suppliers
inquiry