4-Amino-3-nitropyridine synthesis

11synthesis methods

Product Name:4-Amino-3-nitropyridine
CAS Number:1681-37-4
Molecular formula:C5H5N3O2
Molecular Weight:139.11

1796-84-5
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$9.00/250mg

1681-37-4
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$5.00/1g

Yield:1681-37-4 75%

Reaction Conditions:

with ammonium acetate;triethylamine in phosphorus pentaoxide;ethyl acetate

Steps:

2 Preparation of 3-Nitro-4-aminopyridine
EXAMPLE 2 Preparation of 3-Nitro-4-aminopyridine A 25 ml round bottom flask was fitted with a reflux condenser and magnetic stirrer and placed in an oil bath. The flask was charged with 1.0 g (5.95 mmol) of 4-ethoxy-3-nitropyridine and 5.0 g (65 mmol) of ammonium acetate. The reaction mixture was heated at 120° C. to provide a homogeneous liquid. The progress of the reaction was followed by thin layer chromotography employing a 10:1 ethyl acetate:triethylamine solvent system. After 21/2 hours the reaction mixture was cooled and poured into water. The yellow precipitate was collected by filtration, washed with water and dried in vacuo at 60° C. over phosphorus pentoxide. A total of 620 mg of 3-nitro-4-aminopyridine was obtained and chromatographically verified by comparison to an authentic reference standard. Yield 75%.

References:

Eli Lilly and Company US4552967, 1985, A

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