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ChemicalBook >> CAS DataBase List >>AMifaMpridine Phosphate

AMifaMpridine Phosphate

CAS No.
446254-47-3
Chemical Name:
AMifaMpridine Phosphate
Synonyms
6-DAP;3,6-DAP;BRN0110232;BRN 0110232;BRN-0110232;AMifaMpridine Phosphate;KAICRBBQCRKMPO-UHFFFAOYSA-N
CBNumber:
CB32716120
Molecular Formula:
C5H10N3O4P
Molecular Weight:
207.124361
MDL Number:
MFCD28386276
MOL File:
446254-47-3.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:05

AMifaMpridine Phosphate Properties

FDA UNII 8HF8FIN815

AMifaMpridine Phosphate Chemical Properties,Uses,Production

Uses

Amifampridine (3,4-Diaminopyridine) phosphate is an orally active, potent and cell permeable voltage-gated potassium (Kv) channel blocker (PCB). Amifampridine phosphate is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine phosphate increases transmitter release from neuromuscular junctions (NMJs). Amifampridine phosphate can be used for Lambert-Eaton myasthenic syndrome (LEMS) research[1][2][3].

in vivo

Amifampridine phosphate (Oral gavage; 10 mg/kg; once) can antagonize muscle paralysis following BoNT/A intoxication[2].
Amifampridine phosphate (2.5 mg/kg (IV); 10 mg/kg (PO); once) shows 1 hour plasma half-life and about 57% bioavailability (F) in mice[2].
Amifampridine phosphate has a short plasma half-life and can induce seizures when present at high concentrations, following penetration of the blood-brain barrier[2].

Animal Model:CD-1 mouse (female,25 g, 6 weeks old)[2]
Dosage:10 mg/kg
Administration:Oral gavage, once, after BoNT/A administration (IP)
Result:Revealed that neither LEMs alone (182 ± 43 min) nor the maximum safe orally deliverable dose of 3,4-DAP alone (225 ± 24 min) could significantly increase the time to death following toxin administration (216 ± 29 min). However, when the 10/50/40 3,4-DAP/LEM/shellac formulation was administered at 25 mg/kg the time to death was 302 ± 26 min - a 40% increase as compared to toxin alone.
Animal Model:CD-1 mouse (30-35 g, 8 weeks old)[2]
Dosage:2.5 mg/kg (IV); 10 mg/kg (PO)
Administration:IV, orally, once (Pharmacokinetic Analysis)
Result:Pharmacokinetic Parameters of Amifampridine in CD-1 mouse[1].
IV (2.5 mg/kg)PO (10 mg/kg)
t1/2 (h)1.041.28
AUC0-24 (μM·h)4.299.72
F (%)10056.7

References

[1] Maarten J Titulaer, et al. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol. 2011 Dec;10(12):1098-107. DOI:10.1016/S1474-4422(11)70245-9
[2] T L Harris, et al. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication. Chem Commun (Camb). 2016 Mar 18;52(22):4187-90. DOI:10.1039/c6cc00615a
[3] Ojala KS, et al. A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. J Biol Chem. 2021 Jan-Jun;296:100302. DOI:10.1016/j.jbc.2021.100302

54-96-6
446254-47-3
Synthesis of AMifaMpridine Phosphate from 3,4-Diaminopyridine

AMifaMpridine Phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

AMifaMpridine Phosphate Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Wuhan Ruilida Biomedical Technology Co., Ltd. 18201884268 magean83@163.com China 1687 58
Shaanxi Dideu Medichem Co. Ltd 029-029-81124267 15229202216 1073@dideu.com China 10004 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24863 58

View Lastest Price from AMifaMpridine Phosphate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Amifampridine phosphate pictures 2024-10-28 Amifampridine phosphate
446254-47-3
 US $1520.00-2500.00 / mg 10g TargetMol Chemicals Inc.
AMifaMpridine Phosphate KAICRBBQCRKMPO-UHFFFAOYSA-N 6-DAP BRN 0110232 BRN0110232 BRN-0110232 3,6-DAP 446254-47-3