7,8-Dihydroxycoumarin synthesis
- Product Name:7,8-Dihydroxycoumarin
- CAS Number:486-35-1
- Molecular formula:C9H6O4
- Molecular Weight:178.14
471-25-0
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$10.00/1g
87-66-1
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$6.00/10g
486-35-1
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$41.00/250mg
Yield:486-35-1 98%
Reaction Conditions:
with ytterbium(III) trifluoromethanesulfonate hydrate at 80; for 0.0333333 h;Microwave irradiation;Reagent/catalyst;
Steps:
General procedure for coumarin synthesis by MW irradiation
General procedure: An open reaction vessel containing a mixture of the phenol (1.0 mmol), propiolic acid (1.1 mmol), and Yb(OTf)3 hydrate (0.1 mmol) was put in the MW apparatus and irradiated at 200 W (80 °C) for 2 min. The reaction was monitored by TLC (eluent CH2Cl2 / MeOH 99:1). The crude solid obtained was diluted with Et2O and the resulting suspension filtered under vacuum to separate the catalyst, the precipitate washed several times with Et2O. The filtrate was washed twice with a 5% NaHCO3 solution (10 mL) dried over MgSO4 and evaporated to dryness under vacuum yielding the desired product.
References:
Fiorito, Serena;Epifano, Francesco;Taddeo, Vito A.;Genovese, Salvatore [Tetrahedron Letters,2016,vol. 57,# 26,p. 2939 - 2942] Location in patent:supporting information
617-48-1
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87-66-1
686 suppliers
$6.00/10g
486-35-1
287 suppliers
$41.00/250mg
2144-08-3
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$5.00/1g
1099-45-2
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486-35-1
287 suppliers
$41.00/250mg
93-35-6
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$6.00/100mg
486-35-1
287 suppliers
$41.00/250mg
2445-80-9
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486-35-1
287 suppliers
$41.00/250mg