ChemicalBook CAS DataBase List 6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID

6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID synthesis

5synthesis methods

Product Name:6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID
CAS Number:5463-29-6
Molecular formula:C10H6BrNO3
Molecular Weight:268.06

141-82-2 Synthesis

141-82-2
754 suppliers
$5.00/25g

87-48-9
288 suppliers
$10.00/5g

6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID

5463-29-6
53 suppliers
$55.00/250mg

Yield:5463-29-6 76%

Reaction Conditions:

with acetic acid at 130; for 16 h;

Steps:

B.20.1 Step 1

A mixture of R-3 (6.0 g, 26.55 mmol) and R-4 (8.2 g, 79.65 mmol) in acetic acid (25 mL) is stirred at 130^oC for 16h. The reaction mixture is cooled and concentrated under reduced pressure to remove acetic acid. The residue is diluted with water (200 mL), neutralized with saturated aqueous NaHCO₃to pH=7-8 and filtered. The filtrate is acidified with conc. aqueous HCl to pH=1-2, filtered and the solid is dried to afford I-1 (5.4 g, 76%).

References:

WO2021/50913,2021,A1 Location in patent:Paragraph 0304-0305

89446-19-5 Synthesis