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ChemicalBook CAS DataBase List 5-Mercapto-1-methyltetrazole
13183-79-4

5-Mercapto-1-methyltetrazole synthesis

7synthesis methods
-

Yield:13183-79-4 97%

Reaction Conditions:

with sodium azide in ethanol;water at 30 - 70; for 2 h;Microwave irradiation;Temperature;

Steps:

1-3; 1; 2 Example 3
Put 44.5g of sodium azide into a 250mL microwave reaction chamber, add 70mL of water to warm up and dissolve, isothiocyanate Add 125g of methyl ester to 300mL of ethanol to dissolve, and rise to 70C to start dropping ethanol solution of methyl isothiocyanate, temperature control At 30±2°C, the dropwise addition is completed, keep the temperature for 120min, cool down to 45°C, add 6g of activated carbon to decolorize for 1h, filter, distill under reduced pressure, drop After warming to 8°C, filtering and drying, 77 g of crude methylhydroxytetrazole was obtained with a yield of 97% and a purity of 99.7%.

References:

Shandong Jincheng Kerui Chemical Co., Ltd.;Wang Junwei;Shi Youjuan;Fang Zhengwei;Yu Fugang;Cui Baolong CN111187231, 2020, A Location in patent:Paragraph 0032-0041

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