4-(TRIFLUOROACETYLAMINO)-1-BUTANOL synthesis

3synthesis methods

Product Name:4-(TRIFLUOROACETYLAMINO)-1-BUTANOL
CAS Number:128238-43-7
Molecular formula:C6H10F3NO2
Molecular Weight:185.14

13325-10-5 Synthesis

13325-10-5
307 suppliers
$10.00/1g

383-63-1 Synthesis

383-63-1
481 suppliers
$10.00/25g

128238-43-7
12 suppliers
$97.09/1ml

Yield:128238-43-7 100%

Reaction Conditions:

in ethanol at 20;

Steps:

(1) 4-trifluoroacetamidobutanol (Compound 11)

(1)
4-trifluoroacetamidobutanol (Compound 11)
A solution (100 ml) of 4-aminobutanol (2.50 g, 28.05 mmol) and trifluoroacetic acid ethyl ester (19.92 g, 140.26 mmol) in ethanol was stirred at room temperature overnight.
The reaction mixture was concentrated under reduced pressure to give 4-trifluoroacetamidobutanol (11) (5.44 g, q.) as a colorless syrup.

References:

US9404108,2016,B2 Location in patent:Page/Page column 30; 34

13325-10-5 Synthesis

13325-10-5
307 suppliers
$10.00/1g

407-25-0 Synthesis