ChemicalBook CAS DataBase List Methyl trifluoroacetate

Methyl trifluoroacetate synthesis

7synthesis methods

Product Name:Methyl trifluoroacetate
CAS Number:431-47-0
Molecular formula:C3H3F3O2
Molecular Weight:128.05

67-56-1 Synthesis

67-56-1
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431-47-0
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$10.00/5g

Yield:431-47-0 93.8%

Reaction Conditions:

with potassium fluoride at 15; for 4 h;Large scale;

Steps:

4 Example 4
In a reaction kettle with a stirrer, add 40 kg of methanol.Slowly add 58 kg of potassium fluoride and mix the two together to obtain a mixture of ethanol and potassium fluoride.Transfer the mixture of ethanol and potassium fluoride to a closed reactor with a stirrer and start stirring.116 kg of trifluoroacetyl fluoride gas was passed into a mixture of ethanol and potassium fluoride for reaction,The reaction temperature is controlled at about 15 ° C, and the reaction time is controlled at 4 hours.After the reaction is completed, the reaction product is filtered to remove solids (KHF2), and the filtrate is transferred to a rectification column for rectification.120 kg of methyl trifluoroacetate were obtained (93.8% yield).KHF2 removed, which is a solid, neutralized with KOH after dissolving in water,All were converted to KF, which was dehydrated and dried to anhydrous potassium fluoride.

References:

Sanming Haisifu Chemical Co., Ltd.;Cao Wei;Lv Tao;Xie Weidong;Zhang Wei CN104370739, 2016, B Location in patent:Paragraph 0025-0026

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123-76-2 Synthesis