ChemicalBook CAS DataBase List 4-Methoxyphenylacetone

4-Methoxyphenylacetone synthesis

11synthesis methods

Product Name:4-Methoxyphenylacetone
CAS Number:122-84-9
Molecular formula:C10H12O2
Molecular Weight:164.2

Obtained by boiling α- or β-anetholglycol with a 2% solution of sulfuric acid, or from 1-(p-methoxyphenyl)-propan-1,2-ol by treatment with diluted sulfuric acid.

104-46-1
325 suppliers
$5.00/100mg

122-84-9
467 suppliers
$5.00/5g

Yield:122-84-9 85 %Spectr.

Reaction Conditions:

with [Ru(2,6-Cl₂tpp)Cl₂];2,6-dichloropyridine N-oxide in chloroform-d1 at 60; for 2 h;Wacker Oxidation;

Steps:

Alkene substrate (0.1 mmol) and internal standard compound trimethylphenylsilicane(5 μL) were dissolved in CDCl3 (0.5 ml) in an NMR tube to record a ¹H NMR. Then[Ru^IV(TDCPP)Cl2] (2.0 mol%) and Cl2pyNO (1.03 equiv) were added and kept themixture at 60 ^oC. The progress of the reaction was monitored by ¹H NMR. Afterdetermination of the product yield by ¹H NMR spectroscopy, the product ketone wasseparated by flash chromatography on silica gel.

References:

Wang, Zhi-Ming;Sang, Xue-Ling;Che, Chi-Ming;Chen, Jian [Tetrahedron Letters,2014,vol. 55,# 10,p. 1736 - 1739] Location in patent:supporting information