4-FLUOROPHENYLMAGNESIUM BROMIDE synthesis
- Product Name:4-FLUOROPHENYLMAGNESIUM BROMIDE
- CAS Number:352-13-6
- Molecular formula:C6H4BrFMg
- Molecular Weight:199.3
460-00-4
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352-13-6
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Yield:-
Reaction Conditions:
with iodine;magnesium in tetrahydrofuran at 68 - 70; for 1.5 h;Heating / reflux;
Steps:
1 1) 20% solution of 4-fluorophenylmagnesium bromide in tetrahydrofuran
53.5 g of magnesium turnings (2.2 mol) and 0.3 g of iodide are charged into a 4-litres reactor at room temperature under nitrogen. The mixture is then heated to 70°C and a solution of 369.5 g (2.11 mol) of 4-fluorobromobenzene in 1960 ml tetrahydrofuran (5.3 volumes on 4-fluorobromobenzene) is added drop wise, in one hour. After addition the mixture is heated to reflux temperature (68÷70°C) for 30 minutes, then it's cooled to 25°C. 2000g of a 20% solution of 4-fluorophenylmagnesium bromide in tetrahydrofuran are obtained (to be kept under nitrogen and protected from the light).
References:
Adorkem Technology SpA EP1506963, 2005, A1 Location in patent:Page/Page column 4
7439-95-4
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352-13-6
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352-13-6
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65399-05-5
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109-54-6
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352-13-6
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109-54-6
150 suppliers
$9.00/1g
460-00-4
623 suppliers
$6.00/10g
352-13-6
197 suppliers
$40.00/50 mL