3-Chloro-1-(N,N-dimethyl)propylamine synthesis
- Product Name:3-Chloro-1-(N,N-dimethyl)propylamine
- CAS Number:109-54-6
- Molecular formula:C5H12ClN
- Molecular Weight:121.61
5407-04-5
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109-54-6
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Yield:109-54-6 91.07%
Reaction Conditions:
with sodium hydroxide in water at 45; for 2 h;
Steps:
3
The flaky solid NaOH (42.1 g, 1052.5 mmol, 1.0 equiv.) was dissolved in 142.1 g of water, a large amount of heat was released to give an aqueous solution of NaOH, which was cooled to 30 ° C. A solution of CPA.HCl (104 g, 658 mol, 1.0 equiv.) and the above aqueous solution of NaOH was added to a 500 mL two-necked flask and the temperature was raised to 45 ° C and the reaction was started and stirred for 2 h.
Reaction post-treatment:
The reaction solution was cooled to room temperature (30 ° C). The organic layer was separated and collected, and 74.93 g of wet CPA was obtained. The water content was found to be 2.755% and the yield was 91.07% (excluding moisture in the CPA).
References:
CN105294496,2016,A Location in patent:Paragraph 0128; 0129; 0130; 0131; 0132
3179-63-3
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109-54-6
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124-40-3
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109-70-6
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109-54-6
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