ChemicalBook CAS DataBase List 4-Chlorobenzotrifluoride

4-Chlorobenzotrifluoride synthesis

12synthesis methods

Product Name:4-Chlorobenzotrifluoride
CAS Number:98-56-6
Molecular formula:C7H4ClF3
Molecular Weight:180.55

887144-94-7 Synthesis

1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one

887144-94-7
177 suppliers
$19.00/1g

106-47-8 Synthesis

106-47-8
474 suppliers
$5.00/5G

98-56-6
397 suppliers
$11.00/25g

Yield:98-56-6 62%

Reaction Conditions:

Stage #1: 4-chloro-anilinewith hydrogenchloride in cis-1,2-Dichloroethylene;water; for 0.0833333 h;
Stage #2: with tert.-butylnitrite in cis-1,2-Dichloroethylene;water; for 0.333333 h;
Stage #3: Togni's reagent IIwith tetrakis(acetonitrile)copper(I)tetrafluoroborate;sodium carbonate in cis-1,2-Dichloroethylene;water at 50;

Steps:

3 Example three,1-trifluoromethyl-4-chlorobenzene synthesis

Weigh 0.064g 4-chloroaniline,Join with a magnetic stirrer 25mL reaction tube,A mixed solution of HCl (0.13 g) and DCEAfter 5 min of reaction, 0.062 g of t-BuONO was added to the reaction tube,And placed in a salt bath stirring reaction 20min.Weigh 0.3g Tony reagent α,0.314 g of tetraacetonitrile Boron tetrafluoroborate,0.034 g sodium bicarbonate,They are sequentially added to the reaction tube,The reaction was stirred at 50 ° C for 10-20 hours,After the reaction,The reaction solution was filtered,Washed and dried,Further purification by column chromatography gave 0.058 g of colorless liquid (yield 62%).

References:

CN106631680,2017,A Location in patent:Paragraph 0023; 0024