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ChemicalBook CAS DataBase List 4-Chloro-3-nitrobenzotrifluoride
121-17-5

4-Chloro-3-nitrobenzotrifluoride synthesis

3synthesis methods
-

Yield:121-17-5 85%

Reaction Conditions:

with ammonium nitrate;3-(N,N-dimethyldodecylammonium)propanesulfonic acid hydrogen sulphate at 70; for 9 h;Temperature;

Steps:

5 Example 5
In a 25 mL round bottom flask,10 mmol (1.81 g) of p-chlorobenzotrifluoride and 20 mmol (1.2 g) of ammonium nitrate were added in sequence.5mmol (2.2g) of ionic liquid,Mix and stir at 70 ° C for 9 hours.Cooling, standing phase separation,The upper crude product is washed with water and dried under vacuum to obtain pure product 3-nitro-4-chlorobenzotrifluoride.The yield was 85% and the content was more than 99%.

References:

Jiangsu Da Hua Chemical Co., Ltd.;Zheng Longzhou;Zhang Liang;Fang Dong;Li Fuxiang CN108484409, 2018, A Location in patent:Paragraph 0019; 0021; 0026; 0027; 0029

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