4-Butylaniline synthesis
- Product Name:4-Butylaniline
- CAS Number:104-13-2
- Molecular formula:C10H15N
- Molecular Weight:149.23
125639-56-7
10 suppliers
$437.00/1g
104-13-2
220 suppliers
$7.00/5g
Yield:104-13-2 70%
Reaction Conditions:
with sodium azide;trifluoroacetic acid in hexane at 40; for 4 h;Sealed tube;
Steps:
The general procedure for the C-C amination of secondary alcohols is as follows.
General procedure: A 20 ml vial equipped with a magnetic stirring bar was charged with secondary alcohols (0.3 mmol, 1 equiv.), NaN3 (0.75 mmol, 2.5 equiv.), n-hexane (1.0 ml, 0.3 M) and TFA (5.4 mmol, 18 equiv.) or a mixture of TFA (3.6 mmol,12 equiv.) and MeSO3H (1.8 mmol, 6 equiv.). The vial was sealed and stirred under air at 40 °C for 4 h. On completion, the reaction mixture was quenched by 2 M NaOH (5 m), extracted by ethyl acetate (5 × 2 m) and the combined organic phase was washed with brine and dried over Na2SO4. Then the mixture was concentrated and purified by flash chromatography on a short silica gel column.
References:
Liu, Jianzhong;Qiu, Xu;Huang, Xiaoqiang;Luo, Xiao;Zhang, Cheng;Wei, Jialiang;Pan, Jun;Liang, Yujie;Zhu, Yuchao;Qin, Qixue;Song, Song;Jiao, Ning [Nature Chemistry,2019,vol. 11,# 1,p. 71 - 77]
635-46-1
362 suppliers
$5.00/10g
20651-75-6
27 suppliers
$105.00/5g
91-22-5
406 suppliers
$10.00/25g
104-13-2
220 suppliers
$7.00/5g
1156-55-4
4 suppliers
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104-13-2
220 suppliers
$7.00/5g
120-15-0
98 suppliers
$12.00/100mg
20651-75-6
27 suppliers
$105.00/5g
5263-87-6
310 suppliers
$15.00/5g
104-13-2
220 suppliers
$7.00/5g