ChemicalBook CAS DataBase List 4-Bromo-N-phenylbenzamide

4-Bromo-N-phenylbenzamide synthesis

13synthesis methods

Product Name:4-Bromo-N-phenylbenzamide
CAS Number:6846-12-4
Molecular formula:C13H10BrNO
Molecular Weight:276.13

346689-26-7
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$15.00/5mg

6846-12-4
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$28.60/50MG

Yield:6846-12-4 178 mg

Reaction Conditions:

with copper acetylacetonate;ethanol;diethylamine;vasicine at 100; for 12 h;Sealed tube;regioselective reaction;

Steps:

1.3 General procedure for the hydrodehalogenation of o-haloanilides

General procedure: To a stirred solution of the 2-bromoanilide 1xa or 2-iodmoanilide 1xb (1 mmol), Cu(acac)2 (13mg, 0.05 mmol), vasicine (19 mg, 0.1 mmol) and Et2NH (146 mg, 2 mmol), EtOH (5 mL) in a sealed tube at 100 °C for 12 h. After cooled to room temperature, the reaction was concentrated in vacuo and purified by column chromatography to afford respective products.

References:

Li, Min-Xin;Li, Mei-Ling;Tang, Yan-Ling;Sun, Yun;Qu, Lu;Huang, Feng;Mao, Ze-Wei [Journal of Organometallic Chemistry,2021,vol. 943,art. no. 121844] Location in patent:supporting information