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ChemicalBook CAS DataBase List 4-BROMO-3-HYDROXYBENZALDEHYDE
20035-32-9

4-BROMO-3-HYDROXYBENZALDEHYDE synthesis

7synthesis methods
-

Yield:20035-32-9 35.5 g

Reaction Conditions:

with bromine in dichloromethane;water at 0;Inert atmosphere;Solvent;

Steps:

1.4; 2.4; 3.4

Reaction step: 35.4 g of 3-hydroxybenzaldehyde and 212 ml of dichloromethane were added to a clean reaction vessel, and the mixture was replaced with vacuum nitrogen three times, stirred and cooled to below 0 ° C, 35.4 g of liquid bromine was added dropwise, and 250 ml of water was added after completion of the reaction. Adjust the pH to neutral with liquid alkali, filter by cooling, add 354ml of wet product toluene to dissolve, separate the water layer, warm the organic phase to reflux, filter by temperature, and dry to obtain 4-bromo-3-hydroxy-benzaldehyde 35.5. g.

References:

CN109053443,2018,A Location in patent:Paragraph 0025; 0034; 0051-0054; 0059; 0074-0077; 0097-0100

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