3-(4-BROMO-2-FLUORO-3-METHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER synthesis
- Product Name:3-(4-BROMO-2-FLUORO-3-METHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS Number:194804-99-4
- Molecular formula:C12H12BrFO4
- Molecular Weight:319.13
484-94-6
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$41.00/1g
194804-99-4
28 suppliers
$65.00/50 mg
Yield:-
Steps:
Multi-step reaction with 5 steps
1.1: H2 / Pd/C / methanol / 27 h / 20 °C
2.1: aq. HBr; NaNO2 / 0 - 5 °C
2.2: CuBr; aq. HBr / 60 °C
3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C
3.2: tetrahydrofuran; hexane / -78 - 20 °C
4.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
5.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
5.2: 4.70 g / hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C
References:
Wang, Qiuping;Lucien, Edlaine;Hashimoto, Akihiro;Pais, Godwin C. G.;Nelson, David M.;Song, Yongsheng;Thanassi, Jane A.;Marlor, Christopher W.;Thoma, Christy L.;Cheng, Jijun;Podos, Steven D.;Ou, Yangsi;Deshpande, Milind;Pucci, Michael J.;Buechter, Douglas D.;Bradbury, Barton J.;Wiles, Jason A. [Journal of Medicinal Chemistry,2007,vol. 50,# 2,p. 199 - 210]
1526-17-6
196 suppliers
$6.00/1g
194804-99-4
28 suppliers
$65.00/50 mg
845829-94-9
151 suppliers
$35.00/5g
194804-99-4
28 suppliers
$65.00/50 mg
194804-92-7
74 suppliers
$54.00/100mg
194804-99-4
28 suppliers
$65.00/50 mg
437-83-2
174 suppliers
$9.00/250mg
194804-99-4
28 suppliers
$65.00/50 mg