4-BROMO-2-FLUORO-3-METHOXY-BENZOIC ACID synthesis
- Product Name:4-BROMO-2-FLUORO-3-METHOXY-BENZOIC ACID
- CAS Number:194804-92-7
- Molecular formula:C8H6BrFO3
- Molecular Weight:249.03
367-12-4
425 suppliers
$5.00/10g
194804-92-7
74 suppliers
$54.00/100mg
Yield:-
Steps:
Multi-step reaction with 5 steps
1.1: nitric acid / dichloromethane / 1 h / 0 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 - 60 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 2844.39 Torr
4.1: sodium nitrite / water / 1 h / -5 - 0 °C
4.2: 2 h / 0 - 50 °C
5.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -70 °C
References:
MERCK SHARP & DOHME CORP.;PASTERNAK, Alexander;BLIZZARD, Timothy;CHOBANIAN, Harry;DE JESUS, Reynalda;DING, Fa-Xiang;DONG, Shuzhi;GUDE, Candido;KIM, Dooseop;TANG, Haifeng;WALSH, Shawn;PIO, Barbara;JIANG, Jinlong WO2013/28474, 2013, A1
845829-94-9
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$35.00/5g
124-38-9
130 suppliers
$175.00/23402
194804-92-7
74 suppliers
$54.00/100mg
124-38-9
130 suppliers
$175.00/23402
194804-92-7
74 suppliers
$54.00/100mg
1526-17-6
194 suppliers
$6.00/1g
194804-92-7
74 suppliers
$54.00/100mg
484-94-6
97 suppliers
$41.00/1g
194804-92-7
74 suppliers
$54.00/100mg