4,7-Dichloroquinazoline synthesis
- Product Name:4,7-Dichloroquinazoline
- CAS Number:2148-57-4
- Molecular formula:C8H4Cl2N2
- Molecular Weight:199.04
31374-18-2
167 suppliers
$13.00/1g
2148-57-4
133 suppliers
$9.00/100mg
Yield:2148-57-4 94.828%
Reaction Conditions:
with trichlorophosphate at 100; for 3 h;
Steps:
11.1 Example 11 Step 1 - synthesis of 4,7-dichloroquinazoline (171)
7-Chloro-3H- quinazolin-4-one (170, 0.155 g, 0.85830 mmol) was dissolved in 1 mL of POCI3 in a screw cap vial. The vial was sealed and placed in a 100 °C oil bath for 3 hours. The resulting solution was concentrated under vacuum and co-concentrated from toluene three times to provide the desired compound (171, 0.162 g, 0.81391 mmol, 94.828%). MS: 199.0 m/z (M+H)+.
References:
ELAN PHARMACEUTICALS, INC.;XU, Ying-Zi;ARTIS, Dean, R.;BOWERS, Simeon;HOM, Roy, K.;SHAM, Hing, L.;YUAN, Shendong WO2013/142613, 2013, A1 Location in patent:Page/Page column 175
31374-18-2
167 suppliers
$13.00/1g
2148-57-4
133 suppliers
$9.00/100mg
89-77-0
425 suppliers
$6.00/10g
2148-57-4
133 suppliers
$9.00/100mg
5900-58-3
200 suppliers
$11.00/5g
2148-57-4
133 suppliers
$9.00/100mg
5900-59-4
121 suppliers
$8.00/100mg
2148-57-4
133 suppliers
$9.00/100mg