
Oxymetazoline synthesis
- Product Name:Oxymetazoline
- CAS Number:1491-59-4
- Molecular formula:C16H24N2O
- Molecular Weight:260.37

2315-02-8
7 suppliers
$49.00/500mg

1491-59-4
93 suppliers
inquiry
Yield:-
Reaction Conditions:
with ammonium hydroxide at 25 - 30;
Steps:
1.1
To a stirred solution of oxymetazoline hydrochloride (1.0 eq.) in water (20.0 vol), aq. ammonia solution (1.0 vol.) was added at 25-30°C and the reaction mass was stirred for 1-2 h at 25- 30°C. The solid precipitated was filtered, washed with water (5 vol.) and suck dried for 1-2 h. The wet compound was dried under vacuum at 60 - 65°C for about 16 h to afford oxymetazoline as off white solid.
References:
CELLIX BIO PRIVATE LIMITED WO2021/19350, 2021, A1 Location in patent:Paragraph 0063-0064; 0072