ChemicalBook CAS DataBase List 3'-Methylacetophenone

3'-Methylacetophenone synthesis

11synthesis methods

Product Name:3'-Methylacetophenone
CAS Number:585-74-0
Molecular formula:C9H10O
Molecular Weight:134.18

17933-03-8
358 suppliers
$5.00/1g

75-05-8 Synthesis

75-05-8
979 suppliers
$10.00/10g

585-74-0
183 suppliers
$10.00/5g

Yield:585-74-0 83%

Reaction Conditions:

with [2,2]bipyridinyl;palladium diacetate;trifluoroacetic acid in tetrahydrofuran;water at 80; for 36 h;Schlenk technique;Inert atmosphere;

Steps:

Alkyl Aryl Ketones 3 and 2-Arylbenzofurans 4; General Procedure
General procedure: To a Schlenk tube with a magnetic stirring bar were charged the respective nitrile 1 (0.4 mmol), arylboronic acid 2 (0.8 mmol), Pd(OAc)₂ (5 mol%), bpy (10 mol%), TFA (10 equiv), THF (2 mL), and H₂O (0.4 mL) under N₂ atmosphere. The reaction mixture was stirred at 80 °C for 36 h. After cooling to r.t., the mixture was poured into EtOAc (5 mL), which was washed with sat. aq NaHCO₃ (2*10 mL) and then brine (1*10 mL). After extracting the aqueous layer with EtOAc (3*10 mL), the combined organic layers were dried (Na₂SO₄), and evaporated under vacuum. The residue was purified by flash column chromatography (hexane-EtOAc) to afford the desired products 3 or 4. All known compounds afforded analytical data identical to those reported literature previously (see Supporting Information for further details).

References:

Wang, Xingyong;Wang, Xiaodong;Liu, Miaochang;Ding, Jinchang;Chen, Jiuxi;Wu, Huayue [Synthesis,2013,vol. 45,# 16,art. no. SS-2013-F0255-OP,p. 2241 - 2244]

766-82-5 Synthesis