ChemicalBook CAS DataBase List 4'-Methylacetophenone

4'-Methylacetophenone synthesis

13synthesis methods

Product Name:4'-Methylacetophenone
CAS Number:122-00-9
Molecular formula:C9H10O
Molecular Weight:134.18

By slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.

766-97-2 Synthesis

766-97-2
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122-00-9
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Yield:122-00-9 100%

Reaction Conditions:

with water at 59.84; for 24 h;Ionic liquid;

Steps:

Hydration Reaction-In a typical procedure, a solution of phenyl acetylene (1.0 mmol) was mixed with water (3.0 mmol) and BAILs (1.0 mmol). The reaction mixture was stirred for 10 h at 333 K. The reaction mixture was then diluted with H₂O and extracted with chloroform and dried over anhydrous Na₂SO₄. The reaction mixture was analyzed using gas chromatography (Yonglin 6100; BP-5; 30 m × 0.25 mm × 0.25 μm). The products were identified by GC-MS (Shimadzu QP-5000; 30 m long, 0.25 mm i.d., with a 0.25-μm-thick capillary column, DB-1) and authentic samples obtained from Aldrich.Aqueous portion of the reaction mixture was evaporated to remove the water. Residue was washed three-four times with diethyl ether to remove any organic impurity. Finally, ionic liquid portion was dried under vacuum at 353 K for 4 h. The recovered ionic liquid was used in the recycling experiments.

References:

Kore, Rajkumar;Srivastava, Rajendra [Tetrahedron Letters,2012,vol. 53,# 26,p. 3245 - 3249] Location in patent:experimental part

622-97-9 Synthesis