3-FLUORODIPHENYLAMINE synthesis
- Product Name:3-FLUORODIPHENYLAMINE
- CAS Number:500-41-4
- Molecular formula:C12H10FN
- Molecular Weight:187.21
Yield: 75%
Reaction Conditions:
with tris-(dibenzylideneacetone)dipalladium(0);tri-tert-butyl phosphine;sodium t-butanolate in toluene at 80;
Steps:
II.6 6. Sub 2-83 Synthetic Example
The starting material, 1-bromo-3-fluorobenzene (45.3 g, 259.09 mmol)Was dissolved in toluene (1360 ml) in a round bottom flask,aniline (26.54 g, 285.00 mmol), Pd2 (dba) 3 (7.12 g, 7.77 mmol),50% P(t-Bu) 3 (10.1 mL, 20.73 mmol), NaOt-Bu (74.70 g, 777.28 mmol) was added and stirred at 80 [deg.] C.After completion of the reaction, the reaction mixture was extracted with CH2Cl2 and water, and the organic layer was dried over MgSO4The resulting compound was purified by silicagel columnAnd recrystallized to obtain 36.88 g (Yield: 75%) of Sub 2-83.
References:
Duksan Neolux Co.,Ltd.;Jeong Ho-yeong;Ryu Jae-deok;Jeon Jin-bae;Cho Min-ji KR2019/1967, 2019, A Location in patent:Paragraph 0160; 0187-0189