3-Bromofluorobenzene synthesis
- Product Name:3-Bromofluorobenzene
- CAS Number:1073-06-9
- Molecular formula:C6H4BrF
- Molecular Weight:175
108-86-1
507 suppliers
$10.00/5g
1072-85-1
450 suppliers
$5.00/10g
399-94-0
381 suppliers
$6.00/5g
1073-06-9
426 suppliers
$6.00/10g
348-61-8
390 suppliers
$6.00/5g
460-00-4
620 suppliers
$6.00/10g
Yield:1072-85-1 0.06 mmol ，1073-06-9 0.03 mmol ，460-00-4 0.16 mmol ，399-94-0 0.01 mmol ，348-61-8 0.004 mmol
Reaction Conditions:
with xenon difluoride;boron trifluoride diethyl etherate at 0 - 25;Cooling with ice;
Steps:
Reaction of substituted benzenes with xenondifluoride in the presence of boron trifluoride-diethyl ether complex in PFB (procedure A).
General procedure: A FEP or PFA reactor equipped with a Teflon-lined magnetic stir bar and connected to a gas-washing bottle was charged with substituted benzene (0.95-1.10 mmol), 1,1,1,3,3-pentafluorobutane (1-2 mL per mmol of C6H5R), and BF3 · Et2O (1.3-1.5 mmol per mmol of C6H5R). The mixture was stirred for 10-15 min at 0-5°C (ice bath), and XeF2 (1.2-1.3 mmol per mmol of C6H5R) was added in portions. After addition of each portion, the mixture was stirred for 3-5 min at 22-25°C and cooled again. When the addition was complete the dark solution was stirred for 15-30 min at 22-25°C, 10% aqueous KHCO3 was added, and the upper organic layer was separated, passed through a short column charged with silica gel (40-60 μm), and dried over MgSO4. The solution was analyzed by 19F NMR and GC/MS. The main products are given in table, and the others are listed below (GC/MS data).
References:
Bardin;Adonin, N. Yu. [Russian Journal of Organic Chemistry,2016,vol. 52,# 10,p. 1400 - 1407][Zh. Org. Khim.,2016,vol. 52,# 10,p. 1412 - 1419,8]
108-86-1
507 suppliers
$10.00/5g
1072-85-1
450 suppliers
$5.00/10g
1073-06-9
426 suppliers
$6.00/10g
460-00-4
620 suppliers
$6.00/10g
462-06-6
415 suppliers
$10.00/5g
1073-06-9
426 suppliers
$6.00/10g
1121-86-4
256 suppliers
$8.00/5g
1073-06-9
426 suppliers
$6.00/10g