ChemicalBook CAS DataBase List 3,3'-Dimethyl-1,1'-biphenyl-4,4'-diol

3,3'-Dimethyl-1,1'-biphenyl-4,4'-diol synthesis

5synthesis methods

Product Name:3,3'-Dimethyl-1,1'-biphenyl-4,4'-diol
CAS Number:612-84-0
Molecular formula:C14H14O2
Molecular Weight:214.26

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Yield:612-84-0 94.1%

Reaction Conditions:

with toluene-4-sulfonic acid in 5,5-dimethyl-1,3-cyclohexadiene at 130 - 140; for 5 h;Inert atmosphere;Industrial scale;

Steps:

5.2 Example 5: The preparation method of 3,3-dimethyl-4,4-biphenyldiol is described in the present invention

(2) was added to a 200 L stainless steel kettle 3,3'-dimethyl-5,5'-di-t-butyl-4,4'-biphenyldiol 132.6 kg (100mol),m-xylene 1228mol), 144.9g p-toluenesulfonic acid (2mol), nitrogen protection, heating up to 130 ~ 140 ° C, reaction 5h, TCL detection, the end of the reaction, The kettle jacket is cooled to 30 ° C to 40 ° C, and the refrigerant is cooled to -5 ° C to 10 ° C and dried to give 3,3'-dimethyl_4,4'-biphenyldiphenol , Recrystallized from ethanol, and dried in vacuo to give 20.12 kg of white powder, yield 94.1%, purity 99.9% (HPLC)

References:

CN103936560,2016,B Location in patent:Paragraph 0045; 0047