ChemicalBook CAS DataBase List 3-FLUOROCATECHOL

3-FLUOROCATECHOL synthesis

9synthesis methods

Product Name:3-FLUOROCATECHOL
CAS Number:363-52-0
Molecular formula:C6H5FO2
Molecular Weight:128.1

28177-50-6 Synthesis

28177-50-6
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$62.00/1g

363-52-0
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$7.00/250mg

Yield:363-52-0 78%

Reaction Conditions:

Stage #1: 2-fluoro-6-iodophenolwith potassium hydroxide;water for 8 h;Heating / reflux;
Stage #2: with hydrogenchloride;water at 20; pH=2 - 3;

Steps:

5.1

1) Synthesis of 3-fluorocatechol [H]: To a 500 ml flask were added 119 g (0.5 mol) of 2-fluoro-6-iodophenol and 200 ml of a 30% aqueous potassium hydroxide solution and they were reacted under vigorous stirring under a reflux temperature for 8 hours. After the termination of the reaction, the mixture was cooled to ordinary temperature and neutralized with hydrochloric acid to adjust pH between 2 and 3. After filtration, the filtrate was washed with water to obtain 49.9 g of a product [H]. The process yield was 78%.

References:

EP2055692,2009,A1 Location in patent:Page/Page column 9

367-12-4 Synthesis