ChemicalBook CAS DataBase List 3-(2-HYDROXYETHYL)-2-OXAZOLIDINONE

3-(2-HYDROXYETHYL)-2-OXAZOLIDINONE synthesis

14synthesis methods

Product Name:3-(2-HYDROXYETHYL)-2-OXAZOLIDINONE
CAS Number:3356-88-5
Molecular formula:C5H9NO3
Molecular Weight:131.13

111-42-2
832 suppliers
$10.00/20mg

105-58-8
452 suppliers
$15.00/25g

3356-88-5
53 suppliers
$60.00/500mg

Yield:3356-88-5 99%

Reaction Conditions:

in ethylene glycol at 98 - 103; for 12.5 h;Conversion of starting material;

Steps:

32

N-(2-hydroxyethyl)-2-oxazolidinone Starting Materials Diethly carbonate 1.1 mol (130 g) Diethanolamine 0.955 mol (100 g) Ethylene Glycol 230 g. Operating Conditions Pressure Atmospheric Temperature/time regime 98-103° C./12.5 h Reaction Progress Monitored by TLC and using a spot test for diethanolamine (sodium nitroferricyanide/acetaldehyde/aqueous sodium carbonate) Work-up By-product ethanol, excess diethyl carbonate and ethylene glycol (291 mL) were separated from product by distilling at atmospheric pressure first and then at about 20 mm Hg at 25° C. The product fraction weighed 123.9 g, (refraction index 1.482) (literature 1.483) Yield 99%

References:

US2005/27120,2005,A1 Location in patent:Page/Page column 12

201230-82-2 Synthesis