ChemicalBook CAS DataBase List (2-Methoxyphenyl)thiourea

(2-Methoxyphenyl)thiourea synthesis

11synthesis methods

Product Name:(2-Methoxyphenyl)thiourea
CAS Number:1516-37-6
Molecular formula:C8H10N2OS
Molecular Weight:182.24

333-20-0
444 suppliers
$13.50/100G

90-04-0
380 suppliers
$5.00/5 g

1516-37-6
116 suppliers
$10.00/1g

Yield: 84.57%

Reaction Conditions:

with trifluoroacetic acid in acetic acid butyl ester at 80; for 17 h;

Steps:

1
Compound 2 (3.70 g, 0.03 mol) and potassium thiocyanate (4.38 g, 0.045 mol) were dissolved in butyl acetate (30 ml). In an ice bath, TFA (5.74 ml, 0.075 mol) was slowly added dropwise. The mixture was warmed to 80° C. and stirred for 17 h, cooled to room temperature. 6 ml pure water was added, cooled to 0° C. and kept for 1 h. The mixture was filtered by suction under reduced pressure, and then washed with water (grade II), and dried in a vacuum oven to give a white solid 3 (4.77 g, 84.57%).

References:

YANTAI UNIVERSITY;WANG, Hongbo;HONG, Xuechuan;ZHU, Xi;WANG, Pengyu;LV, Guangyao;FU, Jie;LUO, Huairong;ZHANG, Jianqiao;WEN, Meng;QU, Chunrong;ZHU, Jinmei;HU, Xianming US2016/102066, 2016, A1 Location in patent:Paragraph 0021; 0025; 0026