ChemicalBook CAS DataBase List 2-Chlorobenzaldehyde

2-Chlorobenzaldehyde synthesis

14synthesis methods

Product Name:2-Chlorobenzaldehyde
CAS Number:89-98-5
Molecular formula:C7H5ClO
Molecular Weight:140.57

2-Chlorobenzaldehyde is produced mainly by chlorination of 2-chlorotoluene to form 2-chlorobenzal chloride, which is then subjected to acid hydrolysis. Metal salts, such as iron(III) chloride, are used as catalysts. The hydrolysis can also be accomplished using formic acid without a catalyst.
2-Chlorobenzaldehyde can also be produced by oxidation of 2-chlorobenzyl chloride with N-oxides of tertiary amines or with dilute nitric acid.
https://pubchem.ncbi.nlm.nih.gov/compound/2-Chlorobenzaldehyde

873-32-5 Synthesis

873-32-5
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$9.00/1g

89-98-5
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$15.00/25g

Yield:89-98-5 96 %Chromat.

Reaction Conditions:

with lithium diisobutylmorpholinoaluminum hydride in tetrahydrofuran;hexane at 0; for 0.5 h;

Steps:

Partial Reduction of Tertiary Amides and AromaticNitriles to Aldehydes with LDBMOA.

General procedure: The following procedure for reduction of N,N-dimethylbenzamide with LDBMOA is representative. To a solution of N,N-dimethylbenzamide (0.149 g, 1.0 mmol) in THF (10.0 mL) containing naphthalene as an internal standard was added LDBMOA (2.4 mL, 0.5 M in THF-hexanes, 1.2 mmol) at 0 °C. After 30 min, the reaction mixture was hydrolyzed with 1 N aq HCl (10 mL) and extracted with diethyl ether. The combined organic layers were dried over anhydrous magnesium sulfate, and filtered. After the removal of solvents in vacuum and purification of residue by column chromatography on silica gel gave benzaldehyde (0.103 g, 97%).

References:

Kim, Yu Ri;An, Duk Keun [Bulletin of the Korean Chemical Society,2012,vol. 33,# 12,p. 4194 - 4196]