2-CHLORO-N-HYDROXY-BENZAMIDINE synthesis
- Product Name:2-CHLORO-N-HYDROXY-BENZAMIDINE
- CAS Number:56935-60-5
- Molecular formula:C7H7ClN2O
- Molecular Weight:170.6
873-32-5
562 suppliers
$9.00/1g
56935-60-5
45 suppliers
$45.00/10mg
Yield:56935-60-5 85%
Reaction Conditions:
with hydroxylamine hydrochloride;triethylamine in methanol at 20;Reflux;
Steps:
8 5.1.1. General procedure for the synthesis of N'-hydroxybenzimidamides 2a-2k
General procedure: A solution of the appropriate cyanophenyl 1a-1k (0.1 mol), hydroxylamine hydrochloride (0.2 mol), and TEA (0.2 mol) in methanol was left under stirring at room temperature for 1 h, then heated under reflux until the disappearance of the starting materials (TLC analysis). After cooling, the solvent was evaporated to dryness under reduced pressure to give the crude, which was dissolved in ethyl acetate (400 mL) and washed with brine (3 100 mL) and dried with Na2SO4. The ethyl acetate was evaporated under reduced pressure to yield the compounds 2a-2k.
References:
Cai, Jin;Wei, Hongtao;Hong, Kwon Ho;Wu, Xiaoqing;Zong, Xi;Cao, Meng;Wang, Peng;Li, Lushen;Sun, Chunlong;Chen, Bo;Zhou, Gaoxing;Chen, Junqing;Ji, Min [Bioorganic and Medicinal Chemistry,2015,vol. 23,# 13,art. no. 12240,p. 3457 - 3471]
89-98-5
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$16.00/25g
56935-60-5
45 suppliers
$45.00/10mg
29568-74-9
30 suppliers
$60.00/500mg
56935-60-5
45 suppliers
$45.00/10mg
7664-41-7
512 suppliers
$15.00/100ml
29568-74-9
30 suppliers
$60.00/500mg
56935-60-5
45 suppliers
$45.00/10mg