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ChemicalBook CAS DataBase List 2'-CHLORO-4'-HYDROXYACETOPHENONE
41068-36-4

2'-CHLORO-4'-HYDROXYACETOPHENONE synthesis

4synthesis methods
Obtained by reaction of acetyl chloride with 3-chloroanisole in the presence of aluminium chloride (55%), in carbon disulfide (62%) or in 1,2-dichloroethane (81%).
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Yield:41068-36-4 81%

Reaction Conditions:

with aluminium trichloride in 1,2-dichloro-ethane; for 2 h;Ambient temperature;

References:

Gust, Ronald;Burgemeister, Thomas;Mannschreck, Albrecht;Schoenenberger, Helmut [Journal of Medicinal Chemistry,1990,vol. 33,# 9,p. 2535 - 2544]

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