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ChemicalBook CAS DataBase List 2-Amino-6-chloro-3-nitropyridine
27048-04-0

2-Amino-6-chloro-3-nitropyridine synthesis

8synthesis methods
The 2-Amino-6-chloro-3-nitropyridine may be obtained by the ammonolysis of 2,6-dichloro-3-nitropyridine by a known process. The ammonolysis is carried out by using solution of aqueous ammonia in methanol at 35°–40° C. After the reaction is over, the product is obtained by filtration.
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Yield:27048-04-0 92%

Reaction Conditions:

with ammonia in ethanol at 0 - 20;

Steps:

1.2 Synthesis of 2-amino-3-nitro-6-chloropyridine
In the flask were poured into 500mL 200mL anhydrous ethanol at 0 ammonia gas was slowly passed through 2h, and then 4.8g (0.025mol) 2,6- dichloro-3-nitropyridine (V) into the solution at room temperature stir overnight. The reaction is completed clear yellow solution was rotary evaporated to dryness under reduced pressure, ice water was added, filtered, washed with water and dried to give a yellow solid 2-amino-3-nitro-6-chloropyridine (I) 4.0g, 92% yield

References:

Yancheng Teachers College;XU, XIAO JUAN;WANG, JUN;WEI, QING YUN CN103936766, 2016, B Location in patent:Paragraph 0034-0035

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