ChemicalBook CAS DataBase List 2-Amino-5-chlorobenzaldehyde

2-Amino-5-chlorobenzaldehyde synthesis

5synthesis methods

Product Name:2-Amino-5-chlorobenzaldehyde
CAS Number:20028-53-9
Molecular formula:C7H6ClNO
Molecular Weight:155.58

37585-25-4
80 suppliers
$10.00/250mg

20028-53-9
165 suppliers
$6.00/250mg

Yield:20028-53-9 99%

Reaction Conditions:

with manganese(IV) oxide in diethyl ether at 20;

Steps:

Oxidation of (2-amino-phenyl)-methanols (3) to 2-amino-benzaldehydes (4) -General procedure; [0082] (2-Amino-phenyl)-methanol (12 mmol) in dry diethyl ether (25 ml_) is added dropwise to a mixture of manganese dioxide (48 mmol) in dry diethyl ether (25 ml_) and the mixture is stirred at rt overnight. The solution is filtered through a celite and the solvent is removed at reduced pressure. The crude product is used in the next step without further purification.; 2-Amino-5-crtloro-benzaldehyde; Yield 99%; ¹H NMR (CDCI₃): 6.14 (br s, 2H); 6.61 (d, 9 Hz, 1 H); 7.25 (dd, 9 and 2 Hz, 1 H); 7.44 (d, 2 Hz, 1 H) and 9.80 (s, 1 H).

References:

MERZ PHARMA GMBH & CO KGAA;HENRICH, Markus;BAUER, Angela;NAGAL, Jens;SLADEK, Meik;PARSONS, Christopher, Graham, Raphael;DANYSZ, Wojciech;KRAUSS, Valerjans;ROZHKOVS, Jevgenijs;STARCHENKOVS, Igors;TRIFANOVA, Dina WO2010/37533, 2010, A1 Location in patent:Page/Page column 45

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6628-86-0 Synthesis