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ChemicalBook CAS DataBase List 2-Amino-1,3-propanediol
534-03-2

2-Amino-1,3-propanediol synthesis

14synthesis methods
Add 20% 2-nitro-1,3-propanediol methanol solution (1250 g) to 5% palladium/carbon 3.5 g. Hydrogen (70 L, pressure 3MPa) was continuously introduced and reacted at 75°C for 5 hours to obtain serine alcohol solution. The serine alcohol solution is pumped into a high vacuum distillation vessel, vacuumed to 40 pa, and methanol is distilled for reuse. Yield = 97.2%.2-Amino-1,3-propanediol
-

Yield:534-03-2 346.27 kg

Reaction Conditions:

with hexamethylenetetramine;ammonia in water at 50 - 60; for 8 h;Large scale;

Steps:

Amination process

The 2-chloro-1,3-propanediol (420.12kg, 3.80kmol) gained in the previous step is transferred to the amination still A17 or the amination still B18, 20% ammonia water (800.00kg, 9.41kmol) and urotropine ( 15.00kg, 0.11kmol), stirred and heated to 50-60°C for 8h. After the reaction is completed, press filtration to obtain 2-amino-1,3-propanediol (346.27kg) after deamination and dehydration, which is sent for inspection by gas chromatographic analysis, and the analysis results are as follows:

References:

CN113683521,2021,A Location in patent:Paragraph 0048-0051

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