ChemicalBook CAS DataBase List 2-Acetylbenzimidazole

2-Acetylbenzimidazole synthesis

9synthesis methods

Product Name:2-Acetylbenzimidazole
CAS Number:18773-95-0
Molecular formula:C9H8N2O
Molecular Weight:160.17

Add KMnO₄ in batches to 2-(α-hydroxyethyl)benzimidazole, and finally react to obtain 2-Acetylbenzimidazole.

51-17-2 Synthesis

51-17-2
576 suppliers
$14.00/25g

64-19-7 Synthesis

64-19-7
1563 suppliers
$10.00/25ML

18773-95-0
46 suppliers
$324.00/5g

Yield:18773-95-0 100 %

Reaction Conditions:

with acetic anhydride at 20;

Steps:

4.4.3.12. 1-(1H-Benzo[d]imidazole-1-yl)ethan-1-one (3l)

Benzimidazole(0.20 g, 1.7 mmol), Ac2O (3.5 mL, 37.0 mmol) and AcOH (5.0 mL,87.3 mmol) were stirred at RT for 0.5 h. The reaction mixture wasconcentrated under reduced pressure, and then azeotroped with PhMe(x3) to give 1-(1H-benzo[d]imidazole-1-yl)ethan-1-one (270 mg,quant.) as an off-white solid.1H NMR (600 MHz, DMSO-d6) 8.89 (s, 1H), 8.17 (d, J = 7.5 Hz, 1H), 7.76 (d, J = 7.9 Hz, 1H), 7.44-7.35 (m, 2H), 2.75 (s, 3H); 13C NMR(151 MHz, DMSO-d6) 169.1, 144.2, 143.7, 131.2, 125.3, 124.6, 120.0,115.2, 23.7; LCMS m/z 161.0 [M+H]+.

References:

Atkinson, Benjamin N.;Willis, Nicky J.;Zhao, Yuguang;Patel, Chandni;Frew, Sarah;Costelloe, Kathryn;Magno, Lorenza;Svensson, Fredrik;Jones, E. Yvonne;Fish, Paul V. [European Journal of Medicinal Chemistry,2023,vol. 251,art. no. 115132]

51-17-2 Synthesis

51-17-2
576 suppliers
$14.00/25g

75-36-5 Synthesis