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ChemicalBook CAS DataBase List 2-(4-Fluorophenyl)-pyrrolidine
72216-06-9

2-(4-Fluorophenyl)-pyrrolidine synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: triethylamine; chloro-trimethyl-silane / diethyl ether / Schlenk technique; Reflux
1.2: 3 h / Inert atmosphere; Reflux
2.1: sodium tetrahydroborate / methanol; water / 20 °C

References:

Legarda, Pablo D.;García-Rubia, Alfonso;Arrayás, Ramón Gómez;Carretero, Juan C. [Tetrahedron,2018,vol. 74,# 29,p. 3947 - 3954]

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