ChemicalBook CAS DataBase List 2,4,6-Collidine

2,4,6-Collidine synthesis

13synthesis methods

Product Name:2,4,6-Collidine
CAS Number:108-75-8
Molecular formula:C8H11N
Molecular Weight:121.18

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Yield:108-75-8 90%

Reaction Conditions:

with bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate salt;potassium iodide in ethanol at 20; for 1.08333 h;

Steps:

Typical procedure for the deoxygenationof pyridine-N-oxide

General procedure: To a 25-mL flask containing a stirred solution of pyridine-N-oxide (1 mmol, 0.095 g) in EtOH (3 mL), Hendrickson reagent (1 mmol, 0.839 g), and KI (2 mmol, 0.336 g) were added. The mixture was stirred magnetically at room temperature, and monitored by TLC. Upon completion of the reaction, the solvent was evaporated, and then saturated sodium bicarbonate solution (10 mL) was added. The product was extracted with chloroform (3 × 5 mL), and dried over anhydrous MgSO4. The filtrate was evaporated, and pyridine (0.059 g, 75%) was obtained as the sole product.

References:

Khodaei, Mohammad Mehdi;Alizadeh, Abdolhamid;Hezarkhani, Hadis Afshar [Journal of the Iranian Chemical Society,2018,vol. 15,# 8,p. 1843 - 1849]