3-Bromo-2-fluoropyridine synthesis
- Product Name:3-Bromo-2-fluoropyridine
- CAS Number:36178-05-9
- Molecular formula:C5H3BrFN
- Molecular Weight:175.99
52200-48-3
367 suppliers
$11.00/1g
36178-05-9
236 suppliers
$15.00/5g
Yield:36178-05-9 73%
Reaction Conditions:
with cesium fluoride in dimethyl sulfoxide at 130; for 4 h;
Steps:
3-Bromo-2-fluoropyridine(3B')
General procedure: To a solution of 2,3-dichloropyridine(1.00 g, 6.76 mmol) in DMSO (33.8 ml) was added CsF (2.053 g, 13.51mmol) at room temperature. The mixture was stirred at 110 °C under air for 20h. The mixture was quenched with water at room temperature and extracted withEtOAc. The organic layer was separated, washed with water and brine, dried overNa2SO4 and concentrated in vacuo. The residue waspurified by column chromatography (silica gel, eluted with EtOAc in hexane) togive 3-chloro-2-fluoropyridine (0.639 g, 4.86 mmol, 71.9 %) as colorlessoil. Thecompound 3B'-8B' were prepared in amanner similar to that described for 2B'.
References:
Katoh, Taisuke;Tomata, Yoshihide;Tsukamoto, Tetsuya;Nakada, Yoshihisa [Tetrahedron Letters,2015,vol. 56,# 44,p. 6043 - 6046] Location in patent:supporting information
372-48-5
385 suppliers
$5.00/5g
36178-05-9
236 suppliers
$15.00/5g
54231-33-3
182 suppliers
$11.00/250mg
36178-05-9
236 suppliers
$15.00/5g
626-55-1
572 suppliers
$5.00/5 / G
36178-05-9
236 suppliers
$15.00/5g
155444-28-3
24 suppliers
inquiry
626-55-1
572 suppliers
$5.00/5 / G
75-05-8
1015 suppliers
$10.00/10g
36178-05-9
236 suppliers
$15.00/5g
155444-28-3
24 suppliers
inquiry