(S)-N-Boc-3,3-dimethylpyrrolidine-2-carboxylic acid synthesis
- Product Name:(S)-N-Boc-3,3-dimethylpyrrolidine-2-carboxylic acid
- CAS Number:174060-98-1
- Molecular formula:C12H21NO4
- Molecular Weight:243.3
24424-99-5
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Yield:-
Reaction Conditions:
with triethylamine in methanol;dichloromethane;water;N,N-dimethyl-formamide
Steps:
67.3.2 Step 3
Step 2 compound (173 mg, 0.97 mmol) was dissolved in DMF (3 mL)/water (3 mL). To this clear solution was added triethylamine (0.46 mL, 3.18 mmol) and di-t-butyl dicarbonate (0.23 g, 1.06 mmol), and the reaction mixture was stirred at rt for 5 h. The solution was evaporated and the residue chromatographed on silica column using CH2Cl2/methanol (9:1) as eluent to yield t-butyloxy-carbonyl-3,3-dimethyl-dl-proline (200 mg) as an oil (LC/Mass, +ion): 244 (M+H).
References:
Robl, Jeffrey A.;Sulsky, Richard B.;Augeri, David J.;Magnin, David R.;Hamann, Lawrence G.;Betebenner, David A. US2002/19411, 2002, A1
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