4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic acid methyl ester synthesis
- Product Name:4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic acid methyl ester
- CAS Number:168683-02-1
- Molecular formula:C12H19NO4
- Molecular Weight:241.28
24424-99-5
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229613-83-6
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Yield:168683-02-1 99%
Reaction Conditions:
with sodium carbonate in n-heptane;water;
Steps:
4 Example 4
Example 4 17.7 g (0.100 mol) of cis-4-amino-2-cyclopentene-1-carboxylic acid methyl ester hydrochloride, 22.9 g (0.105 mol) of di-tert-butyl dicarbonate, 5.6 g (0.053 mol) of sodium carbonate and 70 mL of heptane were put into a four-necked flask (300 mL volume) and equipped with a thermometer. While this mixture was stirred, 100 mL of water was added, and then the mixture was stirred for 3 hours at room temperature. The organic layer separated after the stirring was stopped. The solvent was distilled off from the organic layer under reduced pressure to give 23.9 g (0.099 mol) of cis-4-tert-butoxycarbonylamino-2-cyclopentene-1-carboxylic acid methyl ester. The yield was 99%.
References:
EP1334969,2003,A1
24424-99-5
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138923-03-2
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168683-02-1
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![(6R,7S)-2-BOC-2-AZA-BICYCLO[2.2.1]HEPT-5-EN-3-ONE](/CAS/GIF/151792-53-9.gif)
151792-53-9
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168958-19-8
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168683-02-1
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![((1R,4S)-2-Azabicyclo[2.2.1]hept-5-en-3-one](/CAS/GIF/79200-56-9.gif)
79200-56-9
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168683-02-1
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$161.00/10g
4157-02-2
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168683-02-1
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