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(1S-cis)-4-Amino-2-cyclopentene-1-methanol synthesis
- Product Name:(1S-cis)-4-Amino-2-cyclopentene-1-methanol
- CAS Number:136522-35-5
- Molecular formula:C6H11NO
- Molecular Weight:113.16
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229177-39-3
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136522-35-5
85 suppliers
$51.03/Price $/50mgs:
Yield: 49%
Reaction Conditions:
with hexahydro-2H-oxepin-2-one in tert-butyl methyl ether
Steps:
3 3.1.1 Preparation of (1R,4S)-1-amino-4-(hydroxymethyl)-2-cyclopentene using lipases
3.1.1.4 11 mg of racemic cis-1-amino-4-(hydroxymethyl)-2-cyclopentene were stirred with 1 ml of methyl tert-butyl ether. 0.02 ml of 6-caprolactone and 20 U of Novozym 435 (immob. lipase from Candida antarctica) at room temperature. After 4 days, (1R,4S)-1-amino-4-(hydroxymethyl)-2-cyclopentene with 87% ee was obtained in 49% yield (HPLC).
References:
Lonza AG US2002/10360, 2002, A1
![CARBAMIC ACID, [4(S)-(HYDROXYMETHYL)-2-CYCLOPENTEN-1-YL]-1,1-DIMETHYLETHYL ESTER, (1R-CIS)-](/CAS/GIF/168960-18-7.gif)
168960-18-7
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$67.00/100mg
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136522-35-5
85 suppliers
$51.03/Price $/50mgs:
![((1R,4S)-2-Azabicyclo[2.2.1]hept-5-en-3-one](/CAS/GIF/79200-56-9.gif)
79200-56-9
224 suppliers
$10.00/1g
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136522-35-5
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![(6R,7S)-2-BOC-2-AZA-BICYCLO[2.2.1]HEPT-5-EN-3-ONE](/CAS/GIF/151792-53-9.gif)
151792-53-9
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136522-35-5
85 suppliers
$51.03/Price $/50mgs:
![2-Azabicyclo[2.2.1]hept-5-en-3-one](/CAS/GIF/49805-30-3.gif)
49805-30-3
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$5.00/5g
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136522-35-5
85 suppliers
$51.03/Price $/50mgs: