ChemicalBook CAS DataBase List 1-Methylpyrrolidine

1-Methylpyrrolidine synthesis

13synthesis methods

Product Name:1-Methylpyrrolidine
CAS Number:120-94-5
Molecular formula:C5H11N
Molecular Weight:85.15

n-methylpyrrolidine was successfully synthesized in an aqueous medium by using methylamine and 1,4-dibromobutane in the presence of catalyst k2co3 at a moderated temperature. here, n-methylpyrrolidine was firstly synthesized via the green chemistry process, in which both the water solvent and potassium carbonate catalyst were inexpensive and environmentally friendly. also, the reaction temperature was quite moderated at 90°C.
green organic synthesis of n-methylpyrrolidine

123-75-1 Synthesis

123-75-1
558 suppliers
$10.00/5g

120-94-5
409 suppliers
$8.00/25g

Yield:120-94-5 93%

Reaction Conditions:

in methanol;

Steps:

3 EXAMPLE 3

EXAMPLE 3 50 g per hour of a mixture of 40% by weight of pyrrolidine and 60% by weight of methanol, which has been vaporized at 165° C, is reacted at 190° C in the apparatus described in Example 1. Conversion is 93% and the yield of N-methylpyrrolidine reaches 89% based on pyrrolidine reacted.

References:

US4105657,1978,A

872-50-4 Synthesis