ChemicalBook CAS DataBase List 1-Fluoro-3-nitrobenzene

1-Fluoro-3-nitrobenzene synthesis

14synthesis methods

Product Name:1-Fluoro-3-nitrobenzene
CAS Number:402-67-5
Molecular formula:C6H4FNO2
Molecular Weight:141.1

394-01-4 Synthesis

394-01-4
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$8.00/5g

402-67-5
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$6.00/5g

Yield:402-67-5 42%

Reaction Conditions:

with 2.9-dimethyl-1,10-phenanthroline;oxygen;copper (I) acetate;silver sulfate;sodium chloride in dimethyl sulfoxide at 160; for 24 h;Schlenk technique;

Steps:

8 Example 8. Synthesis of 2-nitro-4-fluorobenzene.
Silak reaction tube equipped with a magnetic stirrer was charged with 6.2 mg of silver sulfate,36.3 mg of copper acetate, 12.5 mg of 2,9-dimethyl-1,10-o-phenanthroline,37 mg of 2-nitro-4-fluorobenzoic acid, and 17.5 mg of sodium chloride4 mL of dimethyl sulfoxide. Heat 160 ° C in the presence of oxygenReaction for 24 hours. After the reaction was completed, distilled water was added to quench the reaction,Extraction with ethyl acetate 3 times, each time 10mL,The combined organic phases were concentrated to give 14.7 mg of 2-nitro-4-fluorobenzene,The yield is 42%.

References:

Nanchang University;Fu Zhengjiang;Cai Hu;Li Zhaojie;Jiang Ligao CN107325002, 2017, A Location in patent:Paragraph 0067

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369-35-7 Synthesis